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(Widely credited to have been coined by Dr. David Eddy of Kaiser Permanente It is believed that its philosophical base dates back to the sceptics of post-revolutionary France (Xavier Bichat, Pierre Louis, Franois Magendie) The conscientious, explicit and judicious use of current best evidence in making clinical decisions about the care of individual patients (Dr. David Sackett, 1996)Evidence Based Medicine - When? (There is evidence that something works, is good and benefits the patient, do it There is evidence that something does not work, is harmful, does not benefit the patient, do not do it There is insufficient evidence, be conservative, relying on individual clinician expertise !Evidence Based Practice - What?TAny practice that applies up-to-date information from relevant and valid research about the usefulness of various diagnostic tests or the predictive power of prognostic factors or the beneficence of a particular treatment method across healthcare, including education, practice management and health economics, it is said to be EBM-enabled.UU*#@Evidence Based Enablement, but& !!(Mere application of evidence based medicine is in itself simply not good enough. The end results need to be validated. This is done by performing outcomes analysis, preferably on a continuous basis4Outcomes Analysis  What?Outcomes are the result of efforts by healthcare providers to provide optimal care resulting in optimal outcomes (Avedis Donabedian, 1980) Outcomes analysis is a non-prejudiced analysis of the outcome of an event, episode or encounter. Not only are the outcomes of an event, but also the variances between different treatment methodologies are measured. In a clinical setting, it also allows one to find out how well a particular treatment method is faring.(b@b&r  H FOutcomes Analysis  What? [Contd.]$$(Clinical. Was the care or service appropriate, and/or did it achieve desired results, such as restoration of function or reduction of physiological anomaly? Quality of Life. Did the care or service improve the psychosocial well-being of the patient and/or return the patient to his previous role in his personal life or work? Satisfaction. Was the patient satisfied with the care received, especially in the context of access, general perceived quality and cost-effectiveness, timeliness, etc.? dP bbG 4Outcomes Analysis  When?(Continuously in realtime,$:Outcomes Analysis  Where? (($ (Wherever there is clinical data capture is done  both paper-based or electronic.&fEvidence Based Practice & Outcomes Analysis  Why? (4,($(~The old way of depending on a combination of informed guesswork, unsystematic observation, common sense, the consensus views of clinical experts, and the so-called  standard and accepted practice , meaning the treatments and procedures used by most other clinicians in a local community  was fine, but with the addition of enormous amounts of information every day, things are threatening to  get out of control . So, is this way  the only way ? /' The Pain Areas& 27 Kg of guidelines, 3000+ new papers per day, 1000 new Medline articles, 46 randomized clinical trials The number of biomedical journals alone doubling since 1970. Average workload for a clinician of anything between 100 to 200 consultations a week resulting in 5000 to 10000 per year. Add to it the difficulty of relying solely on experience while using 2 million pieces of information all stored in ones memory, ever increasing pressures to provide value-for-money services, raised patient demands and expectations, pressures due to a myriad of obtrusive and mostly confusing regulatory compliances, and rapidly altering business demands. Hmmm& P 0(0The Pain Areas& [Contd.]Every encounter with a patient identifies gaps in our knowledge about the etiology, diagnosis, prognosis, or therapy of their illness. Recent research reveals that even as seasoned clinicians we generate about five knowledge  needs for every in-patient encounter, and two  needs for every three out-patients encounters. 1)FThe Pain Areas& a plausible answer$$(To bridge these gaps and fulfill the  needs , we need to practice evidence based medicine, and to evaluate the best evidence that evidence based medicine is supposed to reveal we need to perform outcomes analysis Practicing medicine based on best evidence in the form of clinical protocols helps as a valid legal cover in malpractice suitsUU2*Best Evidence& Current best evidence is up-to-date information from relevant, valid research about the effects of different forms of healthcare, the potential for harm from exposure to particular agents, the accuracy of diagnostic tests, and the predictive power of prognostic factors. jEvidence Based Medicine  How? The way of seven A s& 66(HEvidence Based Medicine  The Types%%(Diagnostic Here the importance of various observations, value of diagnostic tests, etc. are evaluated in ruling in or out a diagnosis Treatment Here the value of a treatment method or the necessity of a particular medication or procedure is determinedL { l { lEvidence Based Balance Sheet|Examine the evidence that a treatment is effective. If so, then determine the magnitude of its benefits, harms, and costs. }" } kAn evidence based balance sheet is an important tool that supports the practice of evidence based medicine.ll$$Evidence Based Balance Sheet>Display in a compact form the evidence as quantitative estimates of the effects of alternative treatments on all the important outcomes The decision-makers can more easily grasp the consequences of the different options they face. Specially useful for informed shared decision-making between physicians and patients. ?Z?%zDeveloping an Evidence Based Balance Sheet  The 4 Main Steps>>(Identification of the alternative treatments that are available to the patient Identification of the health outcomes (i.e., the outcomes that can be experienced by, and are important to, the people who will receive the treatments) that are affected by the treatments Estimation of the probabilities or magnitudes of each of the health outcomes, for each of the alternative treatments Displaying the information in a table*" b N X &<EBM Balance Sheet  An Example(vOne-year probabilities of outcomes associated with Alendronate 5 mg vs. no drug, for a 55-year-old average-risk woman. wZv 0Problems associated with Evidence Based Practice11( EBM in Clinical ProtocolsfClinical protocols need to be made based on the current best evidence These protocols must undergo continuous revalidation in order to continue to be relevant according to the current best evidence Protocols change according to triage assessments and specialty  so they need to be user and problem-specific&4Z}3Artificially Intelligent Electronic Medical Records44(`An electronic medical record solution that has the artificial intelligence to present the appropriate clinical data capture forms according to mandated clinical guidelines that are user as well as problem-specific Automatically  learns to capture the necessary information according to the best evidence)"1Information Overload 2 Information @ Fingertips22(  Thank You! /456789:;<= > ? @ A BCDGHIJKLMPQ  0` 33` Sf3f` 33g` f` www3PP` ZXdbmo` \ғ3y`Ӣ` 3f3ff` 3f3FKf` hk]wwwfܹ` ff>>\`Y{ff` R>&- {p_/̴>?" dd@,|?" dd@   " @ ` n?" dd@   @@``PR    @ ` ` p>> $(    6؏  `}  T Click to edit Master title style! !  0x  `  RClick to edit Master text styles Second level Third level Fourth level Fifth level!     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Y  ^1 * #  @` Ν <,?   ^1 * #  @` ͝ <?.   ^0 * #  @` ̝ <? .  ^1 * #  @` ˝ <?T   i Inconvenience* #  @` ʝ <?Y  ^? * #  @` ɝ <?  ^? * #  @` ȝ <!?.   ^? * #  @` ǝ <+? .  ^0 * #  @` Ɲ <$6?T  nLong-term benefits* #  @` ŝ <@?Y a3322 * #  @` ĝ <I? b.0003 * #  @` Ý <S?.  c.00084 * #  @`  <]? .  c.00144 * #  @`  <X?T  jSpine fracture* #  @`  <q?Y a1078 * #  @`  <{? c.00093 * #  @`  <ȅ?.  c.00223 * #  @`  <? .  c.00316 * #  @`  <D?T  jWrist fracture* #  @`  <<?Y a7143 * #  @`  <@? c.00014 * #  @`  <?.  c.00032 * #  @`  <p´? .  c.00046 * #  @`  <?T  h Hip fracture*  #  @`  <ִ?Y _NNT* #  @`  <D? g Difference *  #  @`  <?.  aDrug * #  @`  <L? .  dNo Drug *  #  @`  <D?T  aItem* #  @`HB  C TYHB  C TYHB  C TTHB  C YY  B -  9  H  0޽h ? 3380___PPT10.@y 0  %@y(  @r @ S P! `}    'N @ #":. J ' A@ <-? N Evidence based medicine is about improving the quality of patient care. It is just as likely to show that effective interventions are underused as to show that ineffective procedures are over-used( #  @` @@ <@6?'  wViewed as a form of rationing( #  @` >@ <9? N  LUse EPR that have the calculations as well as their interpretations built-in(M L#  @` =@ <<?'  -Demands a high degree of statistics knowledge(. -#  @` ;@ <T? N  1Use refined studies performed real-time using EPR(2 1#  @` :@ <^?'  3The quality and quantity of research mostly unknown(4 3#  @` 8@ <i? N  GUse online searches and make all literature available searchable online(H G#  @` 7@ <s?'  CPoor indexing may lead to frustration of futile literature searches(D C#  @` 5@ <~? N  GOne must seriously doubt our capabilities and question our insecurities(H G#  @` 4@ < ?'  BSearching may only result in discovering gaps in medical knowledge(C B#  @` 2@ <? N  NAvailability in electronic form and increased usage will bring the prices down(O N#  @` 1@ <h?'  2Resources needed to acquire and maintain databases(3 2#  @`  /@ <? N ?Train personnel. This is not an issue with the generation next.(@ ?#  @` .@ <?'  4Lack of skills in computer use and locating evidence(5 4#  @` ,@ <? N aUse EPR( #  @`  +@ <Xǵ?'  >Finding and evaluating the evidence is costly in terms of time(? >#  @`Z )@ <? N Evaluate against opportunity cost, follow-on and abandonment option costs. Evidence based practice wins hands down as a strategic investment( #  @`; (@ <Pݵ?'  mResources and commitments in terms of time and money that needs to be delivered away from actual patient care(n m#  @` &@ <? N qSolutions/Workarounds* #  @` %@ <P?'  dProblems*  #  @`ZB B@ s *1 ?'NZB C@ s *1 ?'NZB D@ s *1 ?''ZB E@ s *1 ?NNZB H@ s *1 ?'NZB M@ s *1 ?  ZB Q@ s *1 ?'NZB ^@ s *1 ?'NZB k@ s *1 ?'NZB x@ s *1 ?' N ZB @ s *1 ?' N ZB @ s *1 ?' N ZB @ s *1 ?' N ZB @ s *1 ?' 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B. Bhattacharyya78Microsoft PowerPoint@0 J@2Sx@$G g  <  y--$xx--'@Arial-. .2 #Evidence Based Medicine & ."System-@Arial-. "2 /Outcomes Analysis  .-@Arial-.  2 /r3.-@Arial-.  2 /zAn .-@Arial-. 2 ;9 Evaluation.-@Arial-. 42 J#Dr. Suman Bhusan Bhattacharyya.-@Arial-. 2 Q7MBBS, ADHA, MBA.-@Arial-. 32 YPresented at IAMI, Chandigarha.-@Arial-.  2 Yt-3.-@Arial-. 2 Yv2003 .-@Arial-. <2 _ #Conference, October 19, 2003, PGI, .-@Arial-. 2 eB Chandigarh.-՜.+,0    nOn-screen ShowscsluWd Arial굴림VerdanaTimes New RomanDefault Design>Evidence Based Medicine & Outcomes Analysis – An EvaluationAn Evaluation"Evidence Based Medicine – What? Evidence Based Medicine - When? Evidence Based Practice - What?#Evidence Based Enablement, but…Outcomes Analysis – What?&Outcomes Analysis – What? [Contd.]Outcomes Analysis – When? Outcomes Analysis – Where? 6Evidence Based Practice & Outcomes Analysis – Why? 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